CEMENTED VERSUS CEMENTLESS FIXATION IN ASEPTIC LOOSENING OF TOTAL HIP ARTHROPLASTY: ASSOCIATION OF OSTEOLYSIS BURDEN WITH HARRIS HIP SCORE
Keywords:
Aseptic loosening, Total hip arthroplasty, Harris Hip Score, Osteolysis (bone resorption), Cemented and cementless fixationAbstract
Aseptic loosening remains a leading cause of revision total hip arthroplasty, where periprosthetic osteolysis and bone defects may substantially compromise hip function. The relationship between the burden and distribution of osteolysis and the Harris Hip Score (HHS), particularly when comparing cemented and cementless fixation, is not fully clarified. This retrospective study included 60 patients who underwent revision total hip arthroplasty for aseptic loosening, divided into 30 cemented and 30 cementless implants. Demographic data, body mass index, HHS, Paprosky acetabular defect type, osteolysis volume at the acetabular and femoral sides, and osteolysis distribution according to Gruen femoral zones and DeLee and Charnley acetabular zones were analyzed. Defect types were treated as ordinal categories, and correlations between HHS and osteolysis volume were evaluated separately for cemented and cementless implants. Differences in HHS according to defect type and zonal involvement were also assessed. In both groups, HHS decreased with increasing Paprosky defect severity, with a stronger association in cemented implants. In cemented hips, lower HHS was significantly associated with greater acetabular osteolysis volume, higher total osteolysis volume, and broader DeLee and Charnley zone involvement. In cementless hips, HHS was more strongly related to femoral and total osteolysis volume, while acetabular osteolysis and acetabular zonal distribution showed weaker and less consistent associations. In revision total hip arthroplasty for aseptic loosening, preoperative hip function assessed by HHS is closely related to the severity, volume, and anatomical distribution of osteolysis, with different patterns observed between cemented and cementless fixation. These findings suggest that osteolysis burden, beyond the mere presence of loosening, should be considered in preoperative assessment and planning of revision strategies.
References
Chen, X., Christ, A., Chung, B., Ton, A., Ballatori, A., Shahrestani, S., Gettleman, B., & Heckmann, N. (2023). Cemented versus Cementless Femoral Fixation for Elective Primary Total Hip Arthroplasty: A Nationwide Analysis of Short-Term Complication and Readmission Rates. Journal of Clinical Medicine, 12. https://doi.org/10.3390/jcm12123945.
Elbardesy, H., Anazor, F., Mirza, M., Aly, M., & Maatough, A. (2023). Cemented versus uncemented stems for revision total hip replacement: A systematic review and meta-analysis. World Journal of Orthopedics, 14, 630 - 640. https://doi.org/10.5312/wjo.v14.i8.630.
Factor, S., Rutenberg, T., Garceau, S., Gold, A., Morgan, S., Snir, N., & Warschawski, Y. (2023). Long term results of total hip arthroplasty with cemented and cementless tapered femoral component. SICOT-J, 9. https://doi.org/10.1051/sicotj/2023014.
Faveere, A., Milne, L., Holder, C., & McDougall, C. (2025). Comparison of Rates of Aseptic Loosening in High Offset Versus Standard Offset Cementless Femoral Stems: An Australian National Joint Registry Cohort Analysis.. The Journal of arthroplasty. https://doi.org/10.1016/j.arth.2025.05.074.
Finger, L., Gong, M., Mirvish, A., Gabrielli, A., Tafti, A., O’Malley, M., Klatt, B., & Plate, J. (2024). Performance of Cementless Hip Arthroplasty Stem Types Based on Consolidated Large Registry Data. Arthroplasty Today, 31. https://doi.org/10.1016/j.artd.2024.101582.
Gallo, J., Goodman, S. B., Konttinen, Y. T., & Raska, M. (2013). Particle disease: Biologic mechanisms of periprosthetic osteolysis in total hip arthroplasty. Innate Immunity, 19(2), 213–224. https://doi.org/10.1177/1753425912451779.
Giardina, F., Castagnini, F., Stea, S., Bordini, B., Montalti, M., & Toni, A. (2018). Short Stems Versus Conventional Stems in Cementless Total Hip Arthroplasty: A Long-Term Registry Study.. The Journal of arthroplasty, 33 6, 1794-1799 . https://doi.org/10.1016/j.arth.2018.01.005.
Hameed, D., McCormick, B., Sequeira, S., Dubin, J., Bains, S., Mont, M., Delanois, R., & Boucher, H. (2024). Cemented vs Cementless Femoral Fixation for Total Hip Arthroplasty Following Femoral Neck Fracture in Patients Aged 65 and Older.. The Journal of arthroplasty. https://doi.org/10.1016/j.arth.2024.01.034.
Hanif, M., Arshad, N., Habib, Y., Shami, A., Rehman, O., Rehman, M., Reyaz, M., & Mumtaz, H. (2023). Effect of cementing technique on aseptic stem loosening in cemented primary total hip arthroplasty: a systematic review and meta-analysis. Annals of Medicine and Surgery, 85, 2884 - 2895. https://doi.org/10.1097/ms9.0000000000000734.
Janssen, L., Wijnands, K., Janssen, D., Janssen, M., & Morrenhof, J. (2018). Do Stem Design and Surgical Approach Influence Early Aseptic Loosening in Cementless THA?. Clinical Orthopaedics and Related Research, 476, 1212–1220. https://doi.org/10.1007/s11999.0000000000000208.
Jud, L., Rüedi, N., Dimitriou, D., Hoch, A., & Zingg, P. (2024). High femoral offset as a risk factor for aseptic femoral component loosening in cementless primary total hip arthroplasty. International Orthopaedics, 48, 1217 - 1224. https://doi.org/10.1007/s00264-024-06116-5.
Kelly, M., Chan, P., Prentice, H., Paxton, E., Hinman, A., & Khatod, M. (2021). Cause-specific revision risk in primary total hip arthroplasty using cemented versus cementless femoral stem fixation in a US cohort.. The Journal of arthroplasty. https://doi.org/10.1016/j.arth.2021.09.020.
Kelly, M., Kagan, R., Zaniletti, I., Hegde, V., De, A., Sassoon, A., Marrache, M., & Khanuja, H. (2025). Decreased Revision Risk with Cementless Collared Metadiaphyseal-Filling Stems Compared to Cemented Fixation in Patients 65 Years and Older.. The Journal of arthroplasty. https://doi.org/10.1016/j.arth.2025.04.033.
Kuyl, E., Agarwal, A., Patel, P., Harris, A., Gu, A., Rao, S., Thakkar, S., & Golladay, G. (2023). Osteoporotic Patients Undergoing Total Hip Arthroplasty Have a Similar 5-Year Cumulative Incidence Rate of Periprosthetic Fracture Regardless of Cemented Versus Cementless Femoral Stem Fixation.. The Journal of arthroplasty. https://doi.org/10.1016/j.arth.2023.11.001.
Man, K., Jiang, L. H., Foster, R., & Yang, X. B. (2017). Immunological responses to total hip arthroplasty. Journal of Functional Biomaterials, 8(3), 33. https://doi.org/10.3390/jfb8030033.
Mannino, A., DeFrance, M., & Germano, J. (2024). Do Cementless, Collared Stems Prevent Aseptic Loosening, Subsidence, and Periprosthetic Fracture in Total Hip Arthroplasty?. Journal of long-term effects of medical implants, 35 1, 25-30 . https://doi.org/10.1615/jlongtermeffmedimplants.2024049747.
Pai, F., Chou, T., , H., Chang, W., Tsai, S., Chen, C., Wu, P., & Chen, W. (2022). Cementless primary or revision stem in revision hip arthroplasty for aseptic stem loosening with Paprosky type I/II femoral defect?. Journal of the Chinese Medical Association : JCMA, 85, 1068 - 1075. https://doi.org/10.1097/jcma.0000000000000792.
Rele, S., O’Bryan, E., Holder, C., Lewis, P., & Di Bella, C. (2024). Collared Cementless Femoral Components Reduce the Revision Rates in Primary Total Hip Arthroplasty Using the Direct Anterior Approach: An Australian Orthopaedic Association National Joint Replacement Registry Study.. The Journal of arthroplasty. https://doi.org/10.1016/j.arth.2024.05.009.
Rocha, A., Somerville, L., Moody, P., Lanting, B., Howard, J., Naudie, D., Mccalden, R., MacDonald, S., & Vasarhelyi, E. (2025). Cementless Versus Cemented Stems in Patients Aged 70 Years or Older Undergoing Total Hip Arthroplasty.. The Journal of arthroplasty. https://doi.org/10.1016/j.arth.2025.02.008.
Salman, L., Khatkar, H., Derbas, J., Radi, M., AlSamhori, J., Al-Atout, W., Alzoubi, O., & Ahmed, G. (2025). Outcomes of cemented taper slip versus composite beam femoral stems in total hip arthroplasty: A systematic review and meta-analysis. Qatar Medical Journal, 2025. https://doi.org/10.5339/qmj.2025.20.
Wagener, N., Hardt, S., Pumberger, M., & Schömig, F. (2024). Comparative analysis of femoral bone loss: uncemented vs. cemented aseptic stem loosening in first-time revision surgery—a retrospective evaluation of 215 patients. Archives of Orthopaedic and Trauma Surgery, 144, 3427 - 3438. https://doi.org/10.1007/s00402-024-05506-z.
Wagner, M., Schönthaler, H., Endstrasser, F., Dammerer, D., Nardelli, P., & Brunner, A. (2021). Mid-Term Results After 517 Primary Total Hip Arthroplasties With a Shortened and Shoulderless Double-Taper Press-Fit Stem: High Rates of Aseptic Loosening.. The Journal of arthroplasty. https://doi.org/10.1016/j.arth.2021.09.004.

