HIGH-INTENSITY LASER THERAPY IN KNEE REHABILITATION: A LITERATURE REVIEW WITH IMPLICATIONS FOR RECOVERY AFTER ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION
Keywords:
high-intensity laser therapy, anterior cruciate ligament reconstruction, knee rehabilitation, literature reviewAbstract
High-intensity laser therapy (HILT) is increasingly used as an adjunct in the rehabilitation of musculoskeletal disorders and knee conditions because of its analgesic, anti-inflammatory and biostimulative effects. The objective of this literature review was to analyze randomized clinical studies published from 2020 to 2025 on the effects of HILT, or a comparable high-intensity electrophysical modality, on pain, muscle strength, range of motion and knee function, with particular interest in rehabilitation following anterior cruciate ligament (ACL) reconstruction. PubMed, Medline and ScienceDirect were searched using terms related to HILT, high-power laser therapy, class IV laser therapy, ACL reconstruction and postoperative knee rehabilitation. Randomized controlled or comparative clinical studies involving adults were considered when sufficient methodological and outcome data were available. No randomized clinical study investigating HILT specifically after ACL reconstruction was identified within the defined period. The eligibility criteria were therefore extended to related knee conditions and high-intensity physical modalities. Ten publications based on studies conducted in Poland, Malaysia, Turkey and North Macedonia were analyzed. Most studies involved patients with knee osteoarthritis, while individual studies examined patellofemoral pain syndrome, lateral epicondylitis and the application of High Tone Power Therapy after ACL reconstruction. The most frequently assessed outcomes were pain intensity, functional status, knee flexion, muscle strength and articular cartilage thickness. Comparative studies generally demonstrated greater improvements in pain, function and mobility following HILT than following low-intensity laser therapy or other electrophysical modalities. Findings concerning High Tone Power Therapy indicate possible benefits for quadriceps strength recovery and reduction of joint effusion after ACL reconstruction; however, this modality cannot be considered direct evidence of the effectiveness of HILT. Interpretation of the overall findings was limited by differences in laser dosage, treatment schedules, outcome instruments, follow-up periods, sample sizes and rehabilitation programs provided to the control groups. Current evidence supports HILT as a potentially useful adjunct in the rehabilitation of selected knee disorders, but remains insufficient to support a firm recommendation for its use during early rehabilitation after ACL reconstruction. The identified research gap justifies future adequately powered randomized trials using standardized laser parameters, clearly defined rehabilitation protocols and outcome measures relevant to postoperative recovery
References
Ahmad, M. A., Moganan, M., A Hamid, M. S., Sulaiman, N., Moorthy, U., Hasnan, N., & Yusof, A. (2023). Comparison between low-level and high-intensity laser therapy as an adjunctive treatment for knee osteoarthritis: A randomized, double-blind clinical trial. Life, 13(7), 1519. https://doi.org/10.3390/life13071519
Akaltun, M. S., Altindag, O., Turan, N., Gursoy, S., & Gur, A. (2021). Efficacy of high intensity laser therapy in knee osteoarthritis: A double-blind controlled randomized study. Clinical Rheumatology, 40(5), 1989–1995. https://doi.org/10.1007/s10067-020-05469-7
Arroyo-Fernández, R., Aceituno-Gómez, J., Serrano-Muñoz, D., & Avendaño-Coy, J. (2023). High-intensity laser therapy for musculoskeletal disorders: A systematic review and meta-analysis of randomized clinical trials. Journal of Clinical Medicine, 12(4), 1479. https://doi.org/10.3390/jcm12041479
Eitzen, I., Holm, I., & Risberg, M. A. (2009). Preoperative quadriceps strength is a significant predictor of knee function two years after anterior cruciate ligament reconstruction. British Journal of Sports Medicine, 43(5), 371–376. https://doi.org/10.1136/bjsm.2008.057059
Ekici, B., & Ordahan, B. (2023). Evaluation of the effect of high-intensity laser therapy (HILT) on function, muscle strength, range of motion, pain level, and femoral cartilage thickness in knee osteoarthritis: Randomized controlled study. Lasers in Medical Science, 38, 218. https://doi.org/10.1007/s10103-023-03887-y
Hart, J. M., Pietrosimone, B., Hertel, J., & Ingersoll, C. D. (2010). Quadriceps activation following anterior cruciate ligament reconstruction: A systematic review of neuromuscular electrical stimulation. Journal of Athletic Training, 45(5), 487–497. https://doi.org/10.4085/1062-6050-45.5.487
Jenkins, S. M., Guzman, A., Gardner, B. B., Bryant, S. A., Rayos del Sol, S., McGahan, P., et al. (2022). Rehabilitation after anterior cruciate ligament injury: Review of current literature and recommendations. Current Reviews in Musculoskeletal Medicine, 15(3), 141–152. https://doi.org/10.1007/s12178-022-09755-y
Kaydok, E., Ordahan, B., Solum, S., & Karahan, A. Y. (2020). Short-term efficacy comparison of high-intensity and low-intensity laser therapy in the treatment of lateral epicondylitis: A randomized double-blind clinical study. Archives of Rheumatology, 35(1), 60–67. https://doi.org/10.5606/ArchRheumatol.2020.7347
Koevska, V., Nikolic-Dimitrova, E., Mitrevska, B., Gjerakaroska-Savevska, C., Gocevska, M., & Kalcovska, B. (2021). Application of high-intensity laser in pain treatment of patients with knee osteoarthritis. Archives of Public Health, 13(2), 78–90. https://doi.org/10.3889/aph.2021.6008
Koevska, V., Nikolikj-Dimitrova, E., Mitrevska, B., Gjerakaroska-Savevska, C., Gocevska, M., Kalcovska, B., Manoleva, M., Gecevska, D., & Krstevska, A. (2025). Comparison of the effects of high-intensity laser with low-intensity laser in patients with knee osteoarthritis. Archives of Public Health, 17(1). https://doi.org/10.3889/aph.2025.6156
Lepley, L. K., & Palmieri-Smith, R. M. (2015). Quadriceps strength, activation, and size correlate with functional performance after anterior cruciate ligament reconstruction. Journal of Athletic Training, 50(7), 716–722. https://doi.org/10.4085/1062-6050-50.6.05
Ogrodzka-Ciechanowicz, K., Głąb, G., Ślusarski, J., & Gądek, A. (2021). Quadriceps muscle strength recovery with the use of high tone power therapy after anterior cruciate ligament reconstruction: A randomized controlled trial. BMC Musculoskeletal Disorders, 22. https://doi.org/10.1186/s12891-021-04862-w
Özgözen, S., Özgözen, A. L., Doruk Analan, P., & İncekaş, C. (2025). Additional effect of high-intensity laser therapy with conventional physiotherapy related to pain and function in patients with knee osteoarthritis: A randomized, double-blind, placebo-controlled, 12-week follow-up study. Lasers in Medical Science. Advance online publication. https://doi.org/10.1007/s10103-025-04516-6
Özlü, O., & Atılgan, E. (2024). The effect of high-intensity laser therapy on pain and lower extremity function in patellofemoral pain syndrome: A single-blind randomized controlled trial. Lasers in Medical Science, 39, 103. https://doi.org/10.1007/s10103-024-04017-y
Palmieri-Smith, R. M., Thomas, A. C., Karvonen-Gutierrez, C., & McLean, S. G. (2008). Isometric quadriceps strength and activation after ACL reconstruction. Medicine & Science in Sports & Exercise, 40(7), 1190–1196.
Şen, S. B., Koçyiğit, B. F., Ortaç, E. A., Kösehasanoğulları, M., & Aygün Bilecik, N. (2025). Comparison of the effects of high-intensity laser therapy and low-level laser therapy in knee osteoarthritis. Clinical Rheumatology, 44(11), 4661–4669. https://doi.org/10.1007/s10067-025-07657-9
Van Melick, N., van Cingel, R. E. H., Brooijmans, F., Neeter, C., van Tienen, T., Hullegie, W., et al. (2016). Evidence-based clinical guidelines for anterior cruciate ligament rehabilitation based on a systematic review and multidisciplinary consensus. British Journal of Sports Medicine, 50(24), 1506–1515. https://doi.org/10.1136/bjsports-2015-095898

