FORMULATION AND EVALUATION OF TWO LORATADINE GEL EMULSIONS
Keywords:
emulgel, loratadine, topical drug delivery, semi-solid dosage forms, gels, emulsionsAbstract
Emulgels represent a promising topical drug delivery system that combines the advantages of emulsions and gels, offering improved stability and patient acceptability. Loratadine, a second-generation antihistamine with poor aqueous solubility, may benefit from incorporation into an emulgel system for topical application. The aim of this study was to compare two loratadine-loaded emulgel formulations differing only the type of surfactant used: sodium lauryl sulfate (SLS) and Tween 20. Both formulations were prepared under identical conditions and evaluated with respect to emulsion stability and consistency of the final emulgel. The formulation containing SLS exhibited reduced emulsion stability and resulted in an emulgel with lower consistency and more fluid behavior after incorporation into the gel base. In contrast, the formulation containing Tween 20 showed improved emulsion stability and produced more homogeneous emulgel with higher consistency. These differences are attributed to the influence of surfactant type on emulsion stability and its interaction with carbomer-based gel network. The findings suggest that non-ionic surfactants such as Tween 20 are more suitable for the development of stabile loratadine emulgel formulations.
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